Open AccessInteractions of aspirin with nonsteroidal antiinflammatory drugs in man
Author(s) -
Rubin Alan,
Rodda Bruce E.,
Warrick Patricia,
Gruber Charles M.,
Ridolfo Anthony S.
Publication year - 1973
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780160508
Subject(s) - aspirin , nonsteroidal , medicine , antiinflammatory drug , pharmacology , antipyretic , plasma concentration , anesthesia , analgesic
Healthy volunteers ingested fenoprofen and indomethacin, each alone or combined with aspirin. Concentrations in plasma of both fenoprofen and indomethacin were reduced significantly when administered with aspirin. Reduction of fenoprofen concentrations depended on the aspirin dosage and occurred whether fenoprofen was administered orally or intravenously. Fenoprofen did not affect plasma concentrations of salicylates. These results emphasize the need to assess carefully the effects of salicylates in comparative clinical trials of nonsteroidal antiinflammatory agents.