Open AccessVirologic Studies on Rheumatoid Arthritis
Author(s) -
Wilkes R. Michael,
Simsarian James P.,
Hopps Hope E.,
Roth Henry,
Decker John L.,
Aptekar Robert G.,
Meyer Harry M.
Publication year - 1973
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780160403
Subject(s) - rheumatoid arthritis , medicine , virus , newcastle disease , immunology , virology
Abstract A search for viral agents associated with rheumatoid arthritis was made using cell lines derived from 64 joint fluids and 41 tissue biopsies (including 29 synovia, 10 rheumatoid nodules, and 2 rheumatoid cartilage). Virus recovery was attempted using a variety of techniques including cell fusion. No viruses were isolated nor were significant patterns of antiviral antibodies found in sera from patients with arthritis. Using seven different viruses, including rubella and Newcastle disease virus, the viral susceptibility of cell lines derived from rheumatoid and nonrheumatoid patients was compared; there was no evidence of significant differences.