Experimental viral arthritis induced with herpes simplex | Zendy

Webb Francis W | Zendy; Bluestone Rodney | Zendy; Goldberg Leonard S | Zendy; Douglas Steven D | Zendy; Pearson Carl M | Zendy

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Experimental viral arthritis induced with herpes simplex

Author(s) -

Webb Francis W,

Bluestone Rodney,

Goldberg Leonard S,

Douglas Steven D,

Pearson Carl M

Publication year - 1973

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780160217

Subject(s) - rheumatoid arthritis , medicine , arthritis , herpes simplex virus , knee arthritis , virus , dermatology , pathology , immunology , osteoarthritis , alternative medicine

A chronic erosive arthritis was produced in rabbits by a single intraarticular injection of herpes simplex virus. Three months after injection, a moderate or severe arthritis was present in the injected knees of all 10 animals; mild or moderate changes were present in 9 of the contralateral (noninjected) knee joints. The histologic changes resemble those of human rheumatoid arthritis. Thus, under certain circumstances, a single exposure to herpes simplex virus appears to provoke chronic arthritis.

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