Open AccessExperimental viral arthritis induced with herpes simplex
Author(s) -
Webb Francis W,
Bluestone Rodney,
Goldberg Leonard S,
Douglas Steven D,
Pearson Carl M
Publication year - 1973
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780160217
Subject(s) - rheumatoid arthritis , medicine , arthritis , herpes simplex virus , knee arthritis , virus , dermatology , pathology , immunology , osteoarthritis , alternative medicine
A chronic erosive arthritis was produced in rabbits by a single intraarticular injection of herpes simplex virus. Three months after injection, a moderate or severe arthritis was present in the injected knees of all 10 animals; mild or moderate changes were present in 9 of the contralateral (noninjected) knee joints. The histologic changes resemble those of human rheumatoid arthritis. Thus, under certain circumstances, a single exposure to herpes simplex virus appears to provoke chronic arthritis.