Open AccessReport of the familial occurrence of systemic lupus erythematosus in male siblings
Author(s) -
Spector David A,
Jampol Lee M,
Hayslett John P
Publication year - 1973
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780160213
Subject(s) - pathogenesis , medicine , disease , immunology , systemic disease , lupus erythematosus , systemic lupus erythematosus , dermatology , immunopathology , antibody
The occurrence of systemic lupus erythematosus (SLE) is reported in 2 pairs of male siblings. Since the occurrence of idopathic SLE is uncommon in the male, these cases provide additional support to the hypothesis that genetic factors play an important role in pathogenesis. Of additional interest in these patients was the varied clinical manifestations of disease between brothers, suggesting that additional factors govern the clinical expression of this disorder.