Open AccessPossible adverse effect of phenoxybenzamine therapy in a patient with progressive systemic sclerosis
Author(s) -
Parker Lewis P.,
Hahn Bevra H.,
Osterland C. Kirk
Publication year - 1972
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780150511
Subject(s) - phenoxybenzamine , medicine , gangrene , progressive systemic sclerosis , adverse effect , systemic circulation , raynaud disease , surgery , dermatology , receptor
A 52‐year‐old male was observed with the recent development of progressive systemic sclerosis (PSS). The most prominent symptoms of the PSS were circulatory, with pain in the digits, severe Raynaud's phenomenon and associated atrophic changes and ulcerations of the fingertips. Therapy with phenoxybenzamine was instituted in an attempt to improve digital blood flow. Rapid development of dry gangrene of several digits was observed over the following month. A possible association between phenoxybenzamine therapy and decreased digital circulation is discussed.