Open AccessOsteoarticular changes in Wilson's disease
Author(s) -
Feller Edward R.,
Schumacher H. Ralph
Publication year - 1972
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780150307
Subject(s) - chondrocalcinosis , medicine , chondromalacia , wrist , arthritis , joint disease , degenerative disease , surgery , disease , osteoarthritis , pathology , patella , alternative medicine
The musculoskeletal system of 17 patients with known Wilson's disease was studied clinically and radiographically. Major abnormalities were seen only in 5 patients over 21 years of age. Multiple calcified loose bodies at the wrists were present in 4, premature degenerative arthritis at the knees with chondromalacia patellae in 4 and chondrocalcinosis at the knees in 2. Mild demineralization was seen at all ages and was present in 9 patients. These unusual wrist and knee changes are infrequently recognized manifestations of Wilson's disease in the adult.