Variations of serum concentrations and half‐life of salicylate in patients with rheumatoid arthritis | Zendy

Paulus Harold E. | Zendy; Siegel Mark | Zendy; Mongan Edward | Zendy; Okun Ronald | Zendy; Calabro John J. | Zendy

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Variations of serum concentrations and half‐life of salicylate in patients with rheumatoid arthritis

Author(s) -

Paulus Harold E.,

Siegel Mark,

Mongan Edward,

Okun Ronald,

Calabro John J.

Publication year - 1971

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780140412

Subject(s) - aspirin , rheumatoid arthritis , medicine , body weight , arthritis , gastroenterology , pharmacology

Unlike most drugs the half‐life of salicylates in the serum of human subjects increases as its concentration increases; this observation was confirmed in nine hospitalized patients with rheumatoid arthritis who received the same weight‐adjusted dose of aspirin. They showed marked variations in the maximum salicylate concentrations attained. A relatively small increase in dose resulted in a large increase in serum level. Therefore, optimum intensive salicylate therapy can be achieved only by individualizing the dose of aspirin.

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