Connective Tissue Activation. I. The Nature, Specificity, Measurement and Distribution of Connective Tissue Activating Peptide | Zendy

Castor C. William | Zendy; Dorstewitz Emily L. | Zendy; Smith Susan F. | Zendy; Ritchie James C. | Zendy

Open Access

Connective Tissue Activation. I. The Nature, Specificity, Measurement and Distribution of Connective Tissue Activating Peptide

Author(s) -

Castor C. William,

Dorstewitz Emily L.,

Smith Susan F.,

Ritchie James C.

Publication year - 1971

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780140107

Subject(s) - connective tissue , glycosaminoglycan , hypermetabolism , adipose tissue , peptide , hyaluronic acid , chemistry , inflammation , pathology , endocrinology , medicine , biochemistry , anatomy

A polypeptide which induces hypermetabolism in normal synovial fibroblasts in tissue culture is described. The metabolic changes induced included a marked increase in hyaluronate formation, lactate formation and glucose uptake; formation of soluble and fibrous collagen was depressed. An assay method is presented which permits quantitative comparisons of samples for connective tissue activating peptide (CTAP) activity. The CTAP appeared to be widely distributed in human tissues, the amount of activity being a function of cell density. A role for CTAP in rheumatoid inflammation is proposed.

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