Open AccessD‐Penicillamine in rheumatoid arthritis
Author(s) -
Zuckner Jack,
Ramsey Robert H.,
Dorner Robert W.,
Gantner Jr George E.
Publication year - 1970
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780130205
Subject(s) - penicillamine , rheumatoid arthritis , medicine , ceruloplasmin , erythrocyte sedimentation rate , rheumatoid factor , titer , gastroenterology , arthritis , lymphocyte , antibody , immunology
D‐penicillamine was administered to 15 patients with rheumatoid arthritis. A fall in the titer of rheumatoid factor was demonstrated in all patients. The sedimentation rate decreased in most patients. There was no consistent alteration in immunoglobulins A, G or M or in lymphocyte transformation attributable to penicillamine. Ceruloplasmin serum levels were lowered significantly in 7 patients. Clinical improvement in the arthritis resulted in 10 patients.