Open AccessThe coincidence of Klinefelter's syndrome and systemic lupus erythematosus
Author(s) -
OrtizNeu Carmen,
LeRoy E. Carwile
Publication year - 1969
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780120312
Subject(s) - medicine , klinefelter syndrome , nephrotic syndrome , anti nuclear antibody , karyotype , immunology , lupus nephritis , glomerulonephritis , nephritis , gastroenterology , dermatology , pathology , autoantibody , kidney , antibody , disease , biology , chromosome , genetics , gene
The clinical features of 3 patients with Klinefelter's syndrome who had manifestations of systemic lupus erythematosus are reported. Two of them, young men with XXY karyotype, developed fever, arthritis, proteinuria, and positive LE cell tests; one of the two also had pleurisy with effusion, and the other, treated intermittently with diphenylhydantoin, developed a hemolytic anemia. The third patient, also with XXY karyotype, developed the nephrotic syndrome and was found to have a proliferative glomerulonephritis and a positive antinuclear factor test. The possible relationship of these patients to the “autoimmune” phenomena observed in chromosomal aberrations is discussed.