Open AccessThe stromal cell reaction of pigmented villonodular synovitis: An electron microscopic study
Author(s) -
Wyllie John C.
Publication year - 1969
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780120307
Subject(s) - pigmented villonodular synovitis , hemosiderin , pathology , electron microscope , fibroblast , stromal cell , histiocyte , cell , fibrocyte , cell type , hyperplasia , synovitis , chemistry , medicine , rheumatoid arthritis , immunology , biochemistry , physics , optics , in vitro
Synovium obtained from a patient with pigmented villonodular synovitis was studied with the electron microscope. Attention was directed to the stromal cell hyperplasia, a histological feature of this disease. It was shown that the participating cells were of two main types. The more abundant cell resembled the fibroblast of connective tissue in general, and appeared capable of collagen and mucopolysaccharide synthesis. The second cell type was similar to a macrophage and contained numerous hemosiderin inclusions.