Open AccessSynovial collagenase: Its presence in culture from joint disease of diverse etiology
Author(s) -
Harris Edward D.,
Cohen George L.,
Krane Stephen M.
Publication year - 1969
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780120206
Subject(s) - collagenase , synovitis , rheumatoid arthritis , medicine , synovectomy , synovial membrane , arthritis , pathology , biopsy , microbial collagenase , joint disease , osteoarthritis , chemistry , enzyme , biochemistry , alternative medicine
Abstract Closed needle biopsy of synovium from inflamed joints yields enough tissue to detect production and/or release of collagenase from these tissues. Collagenase activity was found in synovium from 8 of 8 patients with probable rheumatoid arthritis, in 6 of 9 patients with nonrheumatoid inflammatory synovitis, and in 1 of 6 patients with degenerative joint disease. One of 2 patients with classic rheumatoid arthritis had activity in synovium regrown after synovectomy. Therefore synovial collagenase is not unique to rheumatoid arthritis.