Open AccessEffect of Gold Salts and Other Drugs on the Release and Activity of Lysosomal Hydrolases
Author(s) -
Ennis Robert S.,
Granda Jose Luis,
Posner Aaron S.
Publication year - 1968
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780110605
Subject(s) - gold sodium thiomalate , chemistry , gold salts , acid phosphatase , cathepsin , gold compounds , mechanism of action , cathepsin d , rheumatoid arthritis , enzyme , pharmacology , biochemistry , penicillamine , cathepsin b , auranofin , antirheumatic drugs , in vitro , medicine , antirheumatic agents , combinatorial chemistry , organic chemistry
Acetylsalicylic acid, indomethacin, phen‐ylbutazone, gold thiomalate and gold thioglucose had no protective effect on the release of hydrolases from lysosomes. Only the gold compounds produced a marked inhibition of acid phosphatase, /8‐glucuronidase and cathepsin, obtained from both rabbit liver lysosomes and human synovial fluid. This inhibition is reversible by the addition of a sulfhydryl compound. It is suggested that a possible mechanism of gold action in rheumatoid arthritis is the inhibition of intra‐articular hydrolases.