Effects of Rheumatoid Sera on Fibroblast Proliferation and Hyaluronic Acid Synthesis | Zendy

Castor C. William | Zendy; Wright Deloisteen | Zendy; Buckingham R. B. | Zendy

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Effects of Rheumatoid Sera on Fibroblast Proliferation and Hyaluronic Acid Synthesis

Author(s) -

Castor C. William,

Wright Deloisteen,

Buckingham R. B.

Publication year - 1968

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780110507

Subject(s) - hyaluronic acid , fibroblast , in vitro , titer , rheumatoid arthritis , chemistry , immunology , tissue culture , rheumatoid factor , biochemistry , medicine , antibody , anatomy

Rheumatoid serum depresses synovial fibroblast proliferation in vitro and tends to enhance the rate of hyaluronic acid formed per cellular unit. Quantitatively, the observed effects are not large, are apparently not disease specific, and not related to the titer of rheumatoid factor as measured by latex fixation. An improved method for measuring acid mucopolysaccharide in tissue culture medium is described.

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