Open AccessCorrection of thiazide hyperuricemia by potassium chloride and ammonium chloride
Author(s) -
Zweifler Andrew J.,
Thompson George R.
Publication year - 1965
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780080612
Subject(s) - chlorothiazide , uric acid , hyperuricemia , chemistry , medicine , endocrinology , ammonium chloride , potassium , thiazide , chloride , excretion , ammonium , diuretic , organic chemistry
Large doses of KCl lowered serum uric acid while producing mild, apparently unrelated, uricosuria in four chlorothiazide‐treated subjects. In two control subjects KCl also caused mild uricosuria, but had a negligible effect on serum uric acid concentration. Ammonium chloride decreased serum urate in all six subjects, while urinary uric acid excretion remained essentially unchanged. It is suggested that these changes in serum uric acid are secondary to redistribution of urate among body compartments.