Open AccessInhibition of monosodium urate needle crystal growth
Author(s) -
Allen Donald J.,
Milosovich George,
Mattocks Albert M.
Publication year - 1965
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780080611
Subject(s) - gout , methylene blue , uric acid , supersaturation , crystal growth , crystal (programming language) , chemistry , endocrinology , medicine , biochemistry , crystallography , organic chemistry , photocatalysis , computer science , programming language , catalysis
A study of the growth of needle crystals of monosodium urate was undertaken with the aim of finding inhibitors which might be able to prevent the acute gout attack. Rates of crystal growth at various levels of supersaturation are described. Two potent crystal growth inhibitors, Bismarck brown and methylene blue, were found. They are shown to be adsorbed onto monosodium urate. THAM was found to accelerate needle crystal growth.