Open AccessSalicylate inhibition of cartilage degeneration
Author(s) -
Simmons David P.,
Donald Chrisman O.
Publication year - 1965
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780080506
Subject(s) - sodium salicylate , cartilage , degeneration (medical) , in vivo , articular cartilage , saline , chemistry , in vitro , pharmacology , osteoarthritis , anatomy , medicine , pathology , biochemistry , biology , alternative medicine , microbiology and biotechnology
Sodium salicylate significantly inhibits the ability of saline extracts of human articular cartilage to decrease the viscosity of chondromucoprotein. Two groups of rabbits were subjected to superficial scarification of their knee articular cartilage. Those rabbits receiving sodium salicylate in their diets did not develop many of the degenerative changes seen in the untreated animals. Salicylate inhibition of chondromucoprotein degradation in vitro and cartilage degeneration in vivo has been shown for the first time.