Open AccessThe effects of intra‐articular thiotepa on synovial fluids
Author(s) -
Howes Ronald G.,
Jarvis Basil
Publication year - 1965
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780080403
Subject(s) - thiotepa , synovial fluid , medicine , reversion , rheumatoid arthritis , gamma globulin , white blood cell , immunology , pathology , chemistry , chemotherapy , osteoarthritis , antibody , cyclophosphamide , biochemistry , alternative medicine , phenotype , gene
Study of the synovial fluids of nine patients suffering from rheumatoid arthritis before and four weeks after the injection of thiotepa, showed a significant drop in the total white cell count, a reversion to a more normal differential count and significant reduction in the synovial fluid/serum protein ratio, total proteins and gammaglobulin levels.