Open AccessEffect of orally administered D‐penicillamine on gold deposited in the rat kidney
Author(s) -
Davidson Paul,
Engleman Ephraim P.
Publication year - 1964
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780070407
Subject(s) - penicillamine , gold salts , chelation , kidney , chemistry , pharmacology , excretion , oral administration , medicine , endocrinology , urinary system , inorganic chemistry , rheumatoid arthritis
Although orally administered D‐penicillamine, a chelating agent, is known to enhance urinary excretion of gold in man, studies in experimental animals raised the possibility that renal deposition of gold might increase in the presence of the circulating gold‐penicillamine complex. To investigate this possibility, rats previously treated with a gold salt were given a diet containing the chelating agent for a 28‐day period. The renal content of gold was assayed at the end of the study period. The results showed that administration of D‐penicillamine significantly enhanced the removal of gold from the kidneys.