Open AccessAn isohemagglutinin deficiency in relatives of rheumatoid patients
Author(s) -
Rawson Arnold J.,
Abelson Neva M.
Publication year - 1964
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780070405
Subject(s) - rheumatoid arthritis , asymptomatic , globulin , rheumatoid factor , medicine , immunology , gamma globulin , gastroenterology , antibody
Patients with rheumatoid arthritis belonging to blood group 0 have deficient activity of anti‐A and anti‐B isohemagglutinins in chromatographic fractions containing γ ss , γ 1A and γ 1M globulins. Asymptomatic close relatives of these patients, if they too belong to blood group 0 have deficient isohemagglutinin activity only in an intermediate fraction containing y 1A and y ss globulins. Evidence is presented which suggests that the latter deficiency is attributable to the γ 1A globulin, and is not the result of complexing with rheumatoid factor.