Open AccessSignificance of antibody to DNA in systemic lupus erythematosus
Author(s) -
Casals Salvador P.,
Friou George J.,
Myers Lynn L.
Publication year - 1964
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780070404
Subject(s) - nucleoprotein , complement fixation test , dna , antibody , immunology , titer , systemic lupus erythematosus , lupus erythematosus , medicine , microbiology and biotechnology , biology , serology , disease , pathology , genetics
A study was made of serum antibody to DNA and nucleoprotein in 35 patients with SLE, using immunofluorescent spot techniques. Anti DNA was confirmed by complement fixation and observation of the “shaggy” nuclear fluorescent pattern. A striking correlation was observed between presence of anti DNA and the acute phase of SLE. Anti‐nucleoprotein, the most constant finding, showed only a general correlation of titer with phase of disease. Diagnostic and pathogenetic implications are discussed.