Open AccessEffect of aspirin on circulatory responses to catecholamines
Author(s) -
Strom Esther A.,
Coffman Jay D.
Publication year - 1963
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780060604
Subject(s) - vasoconstriction , epinephrine , norepinephrine , medicine , aspirin , circulatory system , vasodilation , anesthesia , plethysmograph , blood flow , blood pressure , hemodynamics , cardiology , dopamine
Calf and foot blood flow responses to intravenous epinephrine and norepinephrine were studied by venous occlusion plethysmography. Subjects were studied on two control days and after having ingested 3.6 gms. aspirin daily for two days. Epinephrine‐induced vasoconstriction in the foot and vasodilation in the calf were significantly reduced after aspirin as was norepinephrine‐induced vasoconstriction in both the foot and the calf. Skin temperatures confirmed the reduction of cutaneous vasoconstrictor responses by aspirin. Pulse and blood pressure responses were unaffected.