Open AccessAppearance of anticoagulant factors and certain “Autoimmune” antibodies following antigenic stimulation with blood group substances in patients with systemic lupus erythematosus
Author(s) -
Zingale Salvador B.,
Avalos Julio C. Sánchez,
Andrada Juan A.,
Stringa Sergio G.,
Manni Jorge A.
Publication year - 1963
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780060503
Subject(s) - medicine , antibody , immunology , lupus anticoagulant , titer , serology , antigen , stimulation , lupus erythematosus , syphilis , thyroglobulin , human immunodeficiency virus (hiv)
Antibody response to injected isologous blood group substances was measured in 15 patients with systemic lupus erythematosus (S.L.E.) and compared with that of a matched control group. S.L.E. patients responded with higher titers of specific antibodies than did the control group. In addition, the appearance of anticoagulant factors, anti‐thyroglobulin antibodies, anti‐kidney antibodies and false positive serologic tests for syphilis was observed after stimulation. The findings seem to support the view that S.L.E. is associated with an abnormal antibody‐forming system.