Studies in latex agglutination: An approach to the determination of optimum conditions for discrimination between rheumatoids and normals | Zendy

Brooks George W. | Zendy; Cobb Sidney | Zendy

Open Access

Studies in latex agglutination: An approach to the determination of optimum conditions for discrimination between rheumatoids and normals

Author(s) -

Brooks George W.,

Cobb Sidney

Publication year - 1963

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780060303

Subject(s) - agglutination (biology) , gamma globulin , sodium , globulin , latex fixation test , chemistry , rheumatoid arthritis , ionic strength , chromatography , medicine , immunology , antibody , organic chemistry , aqueous solution

Optimum conditions for latex agglutination by rheumatoid factors have been investigated with respect to pH, ionic strength, gamma globulin concentration and heat of inactivation. A large number of sero‐negative cases of rheumatoid arthritis was studied. Best discrimination between rheumatoids and normals was found at pH 8.4 instead of at pH 8.2, with 0.6 per cent instead of 1.0 per cent sodium chloride, without gamma globulin and without heat except for 15 minutes inactivation at 56 C.

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