Open AccessZoxazolamine as a uricosuric agent. II. Clinical evaluation in the treatment of gout
Author(s) -
Reed Elizabeth B.
Publication year - 1962
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780050504
Subject(s) - uricosuric , gout , medicine , creatinine , endocrinology , uric acid , urology , hyperuricemia
Zoxazolamine was a well‐tolerated and effective uricosuric agent in 20 gouty patients treated for 3 to 31 months. Cardiovascular disease adversely affected the uricosuric response. Increases in creatinine clearance during treatment indicate that gout nephropathy may be reversible. Evidence suggesting that inadequate fluid intake may hasten the development of renal complications in gout is presented.