Open AccessThe pathogenesis of mycoplasmal (PPLO) arthritis in rats
Author(s) -
Ward John R.,
Jones Russell S.
Publication year - 1962
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780050205
Subject(s) - polyarthritis , arthritis , pathogenesis , synovitis , ankylosis , medicine , mycoplasma , pathology , immunology , biology , microbiology and biotechnology , surgery
The pathogenesis of mycoplasmal polyarthritis in rats was investigated by cultural and morphologic procedures. Virulent Mycoplasma , injected intravenously, localized in joint structures. Synovitis appeared within several days and rapidly advanced to suppurative arthritis and periosteal new bone formation. Arthritis of interspinal articulations produced hind limb paralysis. Lesions resolved with fibrosis, ankylosis and remodeling of new bone. Histologically, mycoplasmal arthritis resembled other forms of experimental suppurative arthritis, distinguishable only by isolation of the pathogenic agent.