Open AccessZoxazolamine As a Uricosuric Agent. I. Acute Effects in Healthy Non‐Gouty Subjects
Author(s) -
Reed Elizabeth B.,
Feichtmeir Thomas V.,
Craig Shirley G.
Publication year - 1961
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780040509
Subject(s) - probenecid , sulfinpyrazone , uricosuric , gout , medicine , endocrinology , ingestion , concomitant , chemistry , pharmacology , uric acid , hyperuricemia , aspirin
The increase in urate clearance during a six hour period following ingestion of zoxazolamine by healthy non‐gouty subjects is roughly proportional to the dose over the range of 25 mg. to 250 mg. The uricosuric activity of zoxazolamine was not affected by concomitant administration of a number of other drugs, but was enhanced by probenecid and by sulfinpyrazone and was diminished by acetazolamide and by small amounts of salicylate.