Open AccessPathologic observations concerning the cutaneous lesion of progressive systemic sclerosis: An electron microscopic histochemical and immunohistochemical study
Author(s) -
Fisher Edwin R.,
Rodnan Gerald P.
Publication year - 1960
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780030607
Subject(s) - pathology , pathogenesis , immunohistochemistry , connective tissue , lesion , connective tissue disease , medicine , connective tissue disorder , autoimmune disease , disease
The results of a comprehensive histochemical and electron microscopic study of skin biopsies from 15 patients with progressive systemic sclerosis exhibiting varying degrees of sclerodermatous involvement strongly suggest that the alterations in this disorder result from an increase of otherwise normal collagen fibers. The failure to demonstrate preferential localization of gamma globulin or other plasma proteins within these lesions is unlike that observed in other so‐called connective tissue diseases purported to have an immunoallergic pathogenesis.