Open AccessStudies on dexamethasone, a new synthetic steroid, in rheumatoid arthritis—a preliminary report
Author(s) -
Bunim Joseph J.,
Black Roger L.,
Lutwak Leo,
Peterson Ralph E.,
Whedon G. Donald
Publication year - 1958
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780010404
Subject(s) - dexamethasone , rheumatoid arthritis , steroid , corticosteroid , medicine , potassium , endocrinology , sodium , pharmacology , chemistry , hormone , organic chemistry
Observations concerning the antirheumatic and physiologic effects of a new synthetic corticosteroid, dexamethasone, are presented. This preparation, the most potent of any steroid heretofore studied, did not cause sodium retention or potassium loss in doses sufficient to suppress rheumatoid disease. Increased nitrogen and calcium excretion were observed. Further clinical studies are indicated. For the present, it is suggested that the daily dose of dexamethasone should not exceed 4 mg.