Open AccessAnti–tumor necrosis factor α therapy in fifteen patients with AA amyloidosis secondary to inflammatory arthritides: A followup report of tolerability and efficacy
Author(s) -
Gottenberg JacquesEric,
MerleVincent Florence,
Bentaberry Fabrice,
Allanore Yannick,
Berenbaum Francis,
Fautrel Bruno,
Combe Bernard,
Durbach Antoine,
Sibilia Jean,
Dougados Maxime,
Mariette Xavier
Publication year - 2003
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.11163
Subject(s) - medicine , etanercept , infliximab , amyloidosis , proteinuria , renal function , tolerability , aa amyloidosis , gastroenterology , surgery , creatinine , adverse effect , urology , tumor necrosis factor alpha , kidney , familial mediterranean fever , disease
Objective Because anti–tumor necrosis factor α (anti‐TNF) has emerged as a highly effective treatment for numerous inflammatory arthritides, which are a common cause of AA amyloidosis, we retrospectively evaluated the safety and efficacy of anti‐TNF in a nationwide study. Methods The rheumatology departments of all French teaching hospitals were contacted by mail to obtain the files of patients with histologically proven secondary AA amyloidosis and renal involvement who were treated with anti‐TNF. Efficacy was assessed as a sustained decrease in 24‐hour proteinuria and a stable/improved glomerular filtration rate (GFR). Results Among the 15 patients studied, the 24‐hour proteinuria was 4.5 ± 3.6 gm (mean ± SD), creatininemia was 178.4 ± 74.9 μmoles/liter, and GFR was 46 ± 23 ml/minute before starting anti‐TNF. Ten patients received infliximab, 4 received etanercept, and 1 received both types of treatment. The mean followup was 10.4 months. No severe adverse events were recorded; one episode of herpes zoster in the first branch of the trigeminal nerve occurred after one infusion of infliximab. Amyloidosis progressed in 7 patients and was stabilized in 5 patients. Three patients (receiving infliximab alone, infliximab plus methotrexate [MTX], or etanercept plus MTX) experienced rapid, dramatic, and sustained decreases in proteinuria (≥80%), with the GFR increasing 15–78%. Conclusion Anti‐TNF was well‐tolerated and safe in the 15 patients with AA amyloidosis and renal involvement. The pathogenic role of TNF in AA amyloidosis, the sustained proteinuria decrease in 3 patients, and the stabilization of renal parameters in 5 other patients make anti‐TNF a promising candidate to treat AA amyloidosis secondary to inflammatory arthritides.