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Phenanthrylalkanoic acids, V: A useful access to α‐methylphenanthreneacetic acids
Author(s) -
Balo Carmen,
Fernández Franco,
Gómez Generosa,
González Carmen,
López Carmen
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.2503241206
Subject(s) - chemistry , yield (engineering) , amino acid , organic chemistry , combinatorial chemistry , biochemistry , metallurgy , materials science
Abstract A very simple one‐pot monomethylation of phenanthreneacetic acids 2 or of their methyl esters 1 yields α‐methylphenanthreneacetic acids 3 in good yield. Altematively, the process may be extended to the preparation of the corresponding α‐arylisobutyric acids 4.