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Release of ketoprofen from dermal bases in presence of cyclodextrins: Effect of the affinity constant determined in semisolid vehicles
Author(s) -
Orienti I.,
Zecchi V.,
Bertasi V.,
Fini A.
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.2503241201
Subject(s) - ketoprofen , chemistry , cyclodextrin , aqueous solution , diffusion , stability constants of complexes , chromatography , binding constant , membrane , combinatorial chemistry , organic chemistry , binding site , biochemistry , physics , thermodynamics
We describe a method to determine the affinity constant values between Ketoprofen and β‐cyclodextrin and hydroxypropyl‐β‐cyclodextrin in semisolid vehicles. The method is based on the diffusion of the drug, released from semisolid vehicles, through a lipidic non porous membrane. The affinity constants of Ketoprofen towards cyclodextrins as determined in semisolid media better represent the release of the drug from dermal bases than the corresponding values in aqueous systems.