1,2‐dihydro‐3,1‐benzoxazin‐4‐one and 4 H ‐1,2‐dihydro‐pyrido‐[2,3‐ d ]‐[1,3]‐oxazin‐4‐one derivatives as potential prodrugs: Part III: Permeability through excised human skin  in vitro | Zendy

Schwenker Gerhard | Zendy; Chen Jianbing | Zendy

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1,2‐dihydro‐3,1‐benzoxazin‐4‐one and 4 H ‐1,2‐dihydro‐pyrido‐[2,3‐ d ]‐[1,3]‐oxazin‐4‐one derivatives as potential prodrugs: Part III: Permeability through excised human skin in vitro

Author(s) -

Schwenker Gerhard,

Chen Jianbing

Publication year - 1991

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.2503241113

Subject(s) - mefenamic acid , prodrug , chemistry , permeation , drug , stereochemistry , in vitro , chromatography , pharmacology , biochemistry , medicine , membrane

The percutaneous permeation characteristics of 6 potential prodrugs 2–7 in comparison with their parent drug mefenamic acid ( 1 ) in vitro using excised human skin were studied. The results show that all potential prodrugs tested were at least 2.0 times as effective as mefenamic acid; compounds 2 and 7 permeated almost 5 times as quickly as mefenamic acid through excised human skin. The relations between the permeation behaviour, the R M values and the melting points were interpreted.

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