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Anthralin derivatives—inhibition of 5‐lipoxygenase—antipsoriatic efficacy
Author(s) -
Tanzer Helene,
Braun Christine,
Seidel Matthias,
Wiegrebe Wolfgang
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.2503241104
Subject(s) - nordihydroguaiaretic acid , lipoxygenase , chemistry , arachidonate 5 lipoxygenase , lactone , enzyme inhibitor , anthrone , pharmacology , stereochemistry , biochemistry , enzyme , medicine , arachidonic acid
Inhibition of 5‐lipoxygenase by anthralin ( 1 ) and 41 derivatives is determined: the acids 38 and 39 , the lactones 40–42 and 9‐anthrone ( 8 ) are the most potent inhibitors, the lactone 41 reaching the efficacy of nordihydroguaiaretic acid (NDGA). The results were correlated with the hydrophilic/lipophilic balance of the test compounds and their clinical efficacy as far as known. There is no correlation between the “minimum structure” of Krebs and Schaltegger 7) concerning antisoriatic activity and the inhibitory effects against 5‐lipoxygenase.