1,2‐dihydro‐3,1‐benzoxazin‐4‐one and 4 H ‐1,2‐dihydro‐pyrido‐[2,3‐ d ]‐[1,3]‐Oxazin‐4‐one derivatives as potential prodrugs part I: Synthesis | Zendy

Schwenker Gerhard | Zendy; Chen Jianbing | Zendy

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1,2‐dihydro‐3,1‐benzoxazin‐4‐one and 4 H ‐1,2‐dihydro‐pyrido‐[2,3‐ d ]‐[1,3]‐Oxazin‐4‐one derivatives as potential prodrugs part I: Synthesis

Author(s) -

Schwenker Gerhard,

Chen Jianbing

Publication year - 1991

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.2503241009

Subject(s) - prodrug , mefenamic acid , niflumic acid , chemistry , flufenamic acid , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , chromatography

1‐Mono‐ and previously unknown 1,2‐disubstituted 1,2‐dihydro‐3,1‐benzoxazin‐4‐ones 7 and 9, potential prodrugs of flufenamic acid (6) and mefenamic acid (8), and 4 H ‐1,2‐dihydro‐pyrido‐[2,3‐ d ]‐[1,3]‐oxazin‐4‐ones 11, potential prodrugs of niflumic acid (10), were prepared; the structures of all new compounds wereconfirmed by spectroscopic methods.

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