Premium
1,2‐dihydro‐3,1‐benzoxazin‐4‐one and 4 H ‐1,2‐dihydro‐pyrido‐[2,3‐ d ]‐[1,3]‐Oxazin‐4‐one derivatives as potential prodrugs part I: Synthesis
Author(s) -
Schwenker Gerhard,
Chen Jianbing
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.2503241009
Subject(s) - prodrug , mefenamic acid , niflumic acid , chemistry , flufenamic acid , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , chromatography
1‐Mono‐ and previously unknown 1,2‐disubstituted 1,2‐dihydro‐3,1‐benzoxazin‐4‐ones 7 and 9, potential prodrugs of flufenamic acid (6) and mefenamic acid (8), and 4 H ‐1,2‐dihydro‐pyrido‐[2,3‐ d ]‐[1,3]‐oxazin‐4‐ones 11, potential prodrugs of niflumic acid (10), were prepared; the structures of all new compounds wereconfirmed by spectroscopic methods.