Synthesis and hypocholesterolemic activity of some  N ‐diphenylmethylpiperazine derivatives | Zendy

Alivert Antonio | Zendy; Canals Francesc | Zendy; Bonet JuanJulio | Zendy; GómezParra Vicente | Zendy; SánchezAlonso Félix | Zendy

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Synthesis and hypocholesterolemic activity of some N ‐diphenylmethylpiperazine derivatives

Author(s) -

Alivert Antonio,

Canals Francesc,

Bonet JuanJulio,

GómezParra Vicente,

SánchezAlonso Félix

Publication year - 1991

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.2503240907

Subject(s) - bezafibrate , chemistry , chemical synthesis , biological activity , stereochemistry , combinatorial chemistry , pharmacology , in vitro , biochemistry , medicine

The synthesis and preliminary assays as hypocholesterolemic agents of five N ‐diphenylmethylpiperazines are described. The evaluations were carried out in hypercholesterolemic mice and two of these compounds were more effective than bezafibrate in the test employed. The di‐ p ‐chlorosubstituted compounds showed higher activity than their corresponding dechlorinated analogs.

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