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Synthesis and hypocholesterolemic activity of some N ‐diphenylmethylpiperazine derivatives
Author(s) -
Alivert Antonio,
Canals Francesc,
Bonet JuanJulio,
GómezParra Vicente,
SánchezAlonso Félix
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.2503240907
Subject(s) - bezafibrate , chemistry , chemical synthesis , biological activity , stereochemistry , combinatorial chemistry , pharmacology , in vitro , biochemistry , medicine
The synthesis and preliminary assays as hypocholesterolemic agents of five N ‐diphenylmethylpiperazines are described. The evaluations were carried out in hypercholesterolemic mice and two of these compounds were more effective than bezafibrate in the test employed. The di‐ p ‐chlorosubstituted compounds showed higher activity than their corresponding dechlorinated analogs.