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Heterocyclic synthesis with isothiocyantes: Synthesis of several new polyfunctionally substituted thiophene, Δ 4 ‐thiazoline and thiazolidinone derivatives
Author(s) -
Mohareb Rafat Milad,
Sherif Sherif Mourad
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.2503240801
Subject(s) - thiazoline , chemistry , electrophile , adduct , thiophene , chemical synthesis , combinatorial chemistry , bicyclic molecule , organic chemistry , catalysis , biochemistry , in vitro
Facile unequivocal syntheses of the title compounds are reported via “in situ” cyclization of the non‐isolable adducts 2a‐d with α‐halogenated electrophilic compounds. Chemical and spectroscopic evidences for the structures of the new compounds are described.