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Synthesis and biological evaluation of new 4‐oxo‐thiazolidin‐2‐ylidene derivatives as antimicrobial agents
Author(s) -
Chaban Taras,
Matiichuk Yulia,
Chulovska Zoriana,
Tymoshuk Oleksandr,
Chaban Ihor,
Matiychuk Vasyl
Publication year - 2021
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.202100037
Subject(s) - antimicrobial , candida albicans , cryptococcus neoformans , klebsiella pneumoniae , staphylococcus aureus , chemistry , acinetobacter baumannii , pseudomonas aeruginosa , escherichia coli , microbiology and biotechnology , antibacterial activity , bacteria , organic chemistry , biology , biochemistry , genetics , gene
In this study, an efficient synthesis and the antimicrobial activity evaluation of some 4‐oxo‐thiazolidin‐2‐ylidene derivatives are presented. The structures of the target substances were confirmed by using 1 H and 13 C nuclear magnetic resonance spectroscopy, mass spectrometry, infrared spectroscopy, and elemental analysis. The synthesized compounds were evaluated for antimicrobial activity against five bacterial strains ( Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa , and Staphylococcus aureus ) and two fungal strains ( Candida albicans and Cryptococcus neoformans ). It was shown that the compounds in this series possess antibacterial and antifungal activities.