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Structural and biological aspects of natural bridged macrobicyclic peptides from marine resources
Author(s) -
Dahiya Rajiv,
Dahiya Sunita,
Kumar Priyank,
Kumar Radhika V.,
Dahiya Saurabh,
Kumar Suresh,
Saharan Renu,
Basu Paramita,
Mitra Arindam,
Sharma Ajay,
Kashaw Sushil K.,
Patel Jayvadan K.
Publication year - 2021
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.202100034
Subject(s) - bicyclic molecule , chemistry , peptide , stereochemistry , cyclic peptide , metabolic stability , combinatorial chemistry , drug development , biological activity , computational biology , drug , biochemistry , biology , in vitro , pharmacology
Among peptide‐based drugs, naturally occurring bicyclic compounds have been established as molecules with unique therapeutic potential. The diverse pharmacological activities associated with bicyclic peptides from marine tunicates, sponges, and bacteria render them suitable to be employed as effective surrogate between complex and small therapeutic moieties. Bicyclic peptides possess greater conformational rigidity and higher metabolic stability as compared with linear and monocyclic peptides. The antibody‐like affinity and specificity of bicyclic peptides enable their binding to the challenging drug targets. Bridged macrobicyclic peptides from natural marine resources represent an underexplored class of molecules that provides promising platforms for drug development owing to their biocompatibility, similarity, and chemical diversity to proteins. The present review explores major marine‐derived bicyclic peptides including disulfide‐bridged, histidinotyrosine‐bridged, or histidinoalanine‐bridged macrobicyclic peptides along with their structural characteristics, synthesis, structure–activity relationship, and bioproperties.The comparison of these macrobicyclic congeners with linear/monocyclic peptides along with their therapeutic potential are also briefly discussed.