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Natural cyclic polypeptides as vital phytochemical constituents from seeds of selected medicinal plants
Author(s) -
Dahiya Rajiv,
Dahiya Sunita,
Shrivastava Jyoti,
Fuloria Neeraj K.,
Gautam Hemendra,
Mourya Rita,
Fuloria Shivkanya
Publication year - 2021
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.202000446
Subject(s) - phytochemical , linum , chemistry , biological activity , biomolecule , drug discovery , medicinal plants , traditional medicine , chemical constituents , botany , biochemistry , biology , in vitro , medicine , chromatography
Cyclopolypeptides are among the most predominant biomolecules in nature, especially those derived from plant seeds. This category of compounds has gained extraordinary attention due to remarkable variety of structures and valuable biofunctions. These congeners display enormous variation in terms of both structure and function and are the most significant biomolecules due to their widespread bioproperties. The estrogenic activity, immunosuppressive activity, cytotoxicity, vasorelaxant activity, and other properties possessed by cyclic peptides from seeds of plants make these congeners attractive leads for the drug discovery process. The current study covers the important structural features, structure–activity relationship, synthesis methods, and bioproperties of plant seeds‐originated bioactive peptides from Vaccaria segetalis , Linum usitatissimum , and Goniothalamus leiocarpus , which may prove vital for the development of novel therapeutics based on a peptide skeleton.