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Synthesis and anticancer activities of some new coumarin derivatives including the triazole ring and their in silico molecular docking studies
Author(s) -
Menteşe Emre,
Güner Adem,
Polatlı Elifsu,
Emirik Mustafa,
Bektaş Hakan,
Kahveci Bahittin
Publication year - 2021
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.202000284
Subject(s) - in silico , docking (animal) , coumarin , chemistry , cytotoxicity , in vitro , mtt assay , cell culture , triazole , squamous carcinoma , cancer cell , biochemistry , stereochemistry , pharmacology , cancer , carcinoma , biology , medicine , genetics , nursing , organic chemistry , gene
The synthesis, docking study, and investigation of the anticancer activities of some coumarin derivatives containing the triazole ring are reported in this study. The newly synthesized compounds were screened for their in vitro anticancer activity against the cell lines CRL5807 (human bronchioalveolar carcinoma), CRL5826 (human squamous cell carcinoma), MDA‐MB231 (human breast cancer cells), HTB177 (human lung cancer), PC‐3 (human prostate adenocarcinoma), PANC‐1 (human pancreatic cancer cells), used as cancer cells, and CCD34Lu (normal human lung fibroblasts), used as a healthy cell line. Cytotoxicity effects of the samples were determined by the MTT (3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2 H ‐tetrazolium bromide) assay. In silico studies were also performed to explore the binding interactions of the molecules.