Premium
Reprogramming of antibiotics to combat antimicrobial resistance
Author(s) -
Dubey Kashyap K.,
Sharma Manisha
Publication year - 2020
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.202000168
Subject(s) - drug repositioning , repurposing , drug , antimicrobial drug , antimicrobial , drug resistance , multiple drug resistance , drug discovery , reprogramming , antibiotics , pharmacology , drug development , risk analysis (engineering) , chemistry , medicine , biology , bioinformatics , microbiology and biotechnology , ecology , cell , biochemistry
This review outlines a literature‐based approach with illustrative examples of drug repurposing (one molecule, multiple targets), which will be useful in tackling the problem of antimicrobial resistance (AMR). Globally, the demands for new drugs have increased due to multidrug‐resistant pathogens and emerging viruses. Keeping these facts in view, drug repurposing started for utilization of a drug in a different way from a preexisting drug, which reduces the time and cost of development of a new drug. Repurposing increases the potency of a drug and reduces its toxicity level, as it is required in lower amounts, supporting the utilization of the drug as a new therapeutic option. This will be further explored to highlight the application in AMR.