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Catechol‐bearing imidazolium and benzimidazolium chlorides as promising antimicrobial agents
Author(s) -
Karataş Mert O.,
Günal Selami,
Mansur Ahmet,
Alıcı Bülent,
Özdemir İsmail
Publication year - 2020
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.202000013
Subject(s) - candida albicans , enterococcus faecalis , antimicrobial , chemistry , staphylococcus aureus , candida glabrata , catechol , klebsiella pneumoniae , microbiology and biotechnology , acinetobacter baumannii , pseudomonas aeruginosa , escherichia coli , candida dubliniensis , nuclear chemistry , bacteria , organic chemistry , corpus albicans , biochemistry , biology , genetics , gene
Catechol‐containing imidazolium (four) and benzimidazolium chlorides (eight) were synthesized to evaluate their antimicrobial properties. All the compounds were fully characterized using 1 H and 13 C nuclear magnetic resonance, liquid chromatography–mass spectrometry, infrared spectroscopic methods, and elemental analyses. Antimicrobial activities of the compounds were tested against the bacteria Escherichia coli , Pseudomonas aeruginosa , Acinetobacter baumannii , Klebsiella pneumoniae , Staphylococcus aureus , methicillin‐resistant S. aureus (MRSA), Enterococcus faecalis , and the fungal strains Candida albicans and Candida glabrata , and promising results were achieved. The two most important benzyl‐substituted benzimidazolium chlorides, 3l and 3k , showed comparable activity to vancomycin against MRSA.