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Chalcone hybrids and their antimalarial activity
Author(s) -
Cheng Peng,
Yang Linlin,
Huang Xiaodan,
Wang Xuejun,
Gong Maoqing
Publication year - 2020
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201900350
Subject(s) - chalcone , malaria , biology , computational biology , pharmacology , chemistry , stereochemistry , immunology
Malaria, one of the most striking, re‐emerging infectious diseases caused by the genus Plasmodium , places a huge burden on global healthcare systems. A major challenge in the control and eradication of malaria is the continuous emergence of increasingly widespread drug‐resistant malaria, creating an urgent need to develop novel antimalarial agents. Chalcone derivatives are ubiquitous in nature and have become indispensable units in medicinal chemistry applications due to their diverse biological profiles. Many chalcone derivatives demonstrate potential in vitro and in vivo antimalarial activity, so chalcone could be a useful template for the development of novel antimalarial agents. This review covers the recent development of chalcone hybrids as antimalarial agents. The critical aspects of the design and structure–activity relationship of these compounds are also discussed.