Premium
Exploration of (3‐benzyl‐5‐hydroxyphenyl)carbamates as new antibacterial agents against Gram‐positive bacteria
Author(s) -
Liang Huaju,
Cheng Yajuan,
Wang Luxia,
Huang Baoqin,
Zhang Niuniu,
Liang Jie,
Yan Ming
Publication year - 2020
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201900294
Subject(s) - enterococcus faecalis , bacteria , staphylococcus epidermidis , chemistry , antibacterial activity , staphylococcus aureus , gram positive bacteria , minimum inhibitory concentration , microbiology and biotechnology , enterococcus , carbamate , antibacterial agent , gram negative bacteria , inhibitory postsynaptic potential , staphylococcus , escherichia coli , antibiotics , biochemistry , biology , genetics , neuroscience , gene
A series of (3‐benzyl‐5‐hydroxyphenyl)carbamates were evaluated as new antibacterial agents. Several compounds showed potent inhibitory activity against sensitive and drug‐resistant Gram‐positive bacteria. The compounds are ineffective against all tested Gram‐negative bacteria. The structure of the ester group exerted a profound effect on antibacterial activity. 4,4‐Dimethylcyclohexanyl carbamate 6h exhibited the most potent inhibitory activity against the standard and clinically isolated Staphylococcus aureus , Staphylococcus epidermidis , and Enterococcus faecalis (minimum inhibitory concentration = 4–8 µg/ml) strains. The preliminary experimental evidence indicated that these carbamates target the bacterial cell wall and share a similar mechanism of action with vancomycin.