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A new series of Schiff base derivatives bearing 1,2,3‐triazole: Design, synthesis, molecular docking, and α‐glucosidase inhibition
Author(s) -
NasliEsfahani Ensieh,
MohammadiKhanaposhtani Maryam,
Rezaei Sepideh,
Sarrafi Yaghoub,
Sharafi Zeinab,
Samadi Nasser,
Faramarzi Mohammad Ali,
Bandarian Fatemeh,
Hamedifar Haleh,
Larijani Bagher,
Hajimiri Mirhamed,
Mahdavi Mohammad
Publication year - 2019
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201900034
Subject(s) - acarbose , schiff base , docking (animal) , chemistry , stereochemistry , active site , 1,2,4 triazole , enzyme , triazole , combinatorial chemistry , non competitive inhibition , biochemistry , organic chemistry , medicine , nursing
A series of new Schiff bases bearing 1,2,3‐triazole 12a ‒ o was designed, synthesized, and evaluated as α‐glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α‐glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α‐glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α‐glucosidase.