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Synthesis, characterization, and in vitro effect of the Cu(II) complex with niflumic acid and 3‐picoline on paraoxanase‐I
Author(s) -
Dilek Esra,
Caglar Sema,
Çardak Seda,
Karakoç Barış,
Caglar Bülent,
Sahin Onur
Publication year - 2019
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201900007
Subject(s) - niflumic acid , chemistry , triclinic crystal system , stereochemistry , crystal structure , crystallography , biochemistry
Niflumic acid is used to treat inflammatory rheumatoid diseases, pain, and fever. The present study reports the experimental, spectroscopic, thermal, structural analyses, and biological activities of this complex. The nonsteroidal anti‐inflammatory drug niflumic acid, 3‐picoline, and copper(II) chloride were utilized to synthesize a new complex: [Cu 2 Cl 2 (nif) 2 (3‐pic) 4 ]. The crystal structure of [Cu 2 Cl 2 (nif) 2 (3‐pic) 4 ] was determined by X‐ray crystallography. The complex crystallizes in the triclinic space group P‐1 and each Cu(II) center displayed six‐coordinated distorted octahedral geometry. Two Cu(II) centers are connected by a chloro‐bridge to form the binuclear metal core. Finally, the in vitro effects of the synthesized new complex and free niflumic acid were evaluated on the human serum paraoxonase 1 enzyme. At low doses, both the new complex and free niflumic acid showed very good inhibition activity with different inhibition mechanisms. In addition, the results showed that the new complex has more inhibition activity than free niflumic acid.