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Novel sulfamate derivatives of menthol: Synthesis, characterization, and cholinesterases and carbonic anhydrase enzymes inhibition properties
Author(s) -
Daryadel Shahla,
Atmaca Ufuk,
Taslimi Parham,
Gülçin İlhami,
Çelik Murat
Publication year - 2018
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201800209
Subject(s) - chemistry , menthol , butyrylcholinesterase , carbonic anhydrase , enzyme , acetylcholinesterase , cholinesterase , carbonic anhydrase i , carbonic anhydrase ii , stereochemistry , biochemistry , organic chemistry , aché , pharmacology , medicine
Sulfamates have a large spectrum of biological activities including enzyme inhibition. Eight sulfamates derived from menthol ( 2a–h ) were synthesized. Also, in the other section of this study, novel sulfamate derivatives of menthol were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carbonic anhydrase I and II enzymes (hCAs I and II). The newly synthesized novel menthol sulfamate and menthol carbonyl sulfamate derivatives showed K i values in the range of 34.37 ± 8.17 to 53.40 ± 10.61 nM against hCA I, 12.91 ± 4.57 to 38.67 ± 6.22 nM against hCA II, 111.17 ± 52.36 to 522.86 ± 120.08 nM against AChE, and 50.01 ± 11.73 to 109.63 ± 50.08 nM against BChE. As a result, the novel menthol sulfamate and menthol carbonyl sulfamate derivatives can be promising Alzheimer's disease drug candidates and novel hCA I and hCA II enzymes inhibitors.