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6‐Nitroazolo[1,5‐ a ]pyrimidin‐7(4 H )‐ones as Antidiabetic Agents
Author(s) -
Spasov Alexander A.,
Babkov Denis A.,
Sysoeva Valentina A.,
Litvinov Roman A.,
Shamshina Darya D.,
Ulomsky Evgeny N.,
Savateev Konstantin V.,
Fedotov Viktor V.,
Slepukhin Pavel A.,
Chupakhin Oleg N.,
Charushin Valery N.,
Rusinov Vladimir L.
Publication year - 2017
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201700226
Subject(s) - chemistry , stereochemistry , pharmacology , combinatorial chemistry , traditional medicine , medicine
Prevention of the formation of advanced glycation end‐products (AGEs) is a reliable approach to achieve control over hyperglycemia and the associated pathogenesis of diabetic vascular complications. In these terms, new synthetic approaches to 6‐nitroazolo[1,5‐ a ]pyrimidines have been developed on the basis of the promising antiglycation activity of their structural analogues, such as azolo[5,1‐ c ][1,2,4]triazine‐4(1 H )‐ones. A number of nitroazolopyrimidines were obtained by using nitration, chlorodeoxygenation, and amination reactions, and their antidiabetic properties were elucidated in vitro . It was shown that triazolo[1,5‐ a ]pyrimidine‐7(4 H )‐ones exhibit a higher antiglycation activity than the corresponding 7‐alkylamino analogs and aminoguanidine, as the reference compound. It is suggested that this kind of activity can be associated with the chelating properties possessed by the synthesized 6‐nitro‐7‐oxoderivatives. Furthermore, the compounds obtained were tested for their inhibitory activity against dipeptidyl peptidase 4 (DPP4), glycogen phosphorylase, and α‐glucosidase in vitro , but their activities proved to be significantly inferior to those of the reference compounds.