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Practical Synthesis of α‐Amyrin, β‐Amyrin, and Lupeol: The Potential Natural Inhibitors of Human Oxidosqualene Cyclase
Author(s) -
Chen Dongyin,
Xu Fengguo,
Zhang Pu,
Deng Jie,
Sun Hongbin,
Wen Xiaoan,
Liu Jun
Publication year - 2017
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201700178
Subject(s) - lupeol , chemistry , pharmacology , biochemistry , biology
A practical synthesis of α‐amyrin ( 1 ), β‐amyrin ( 2 ), and lupeol ( 3 ) was accomplished in total yields of 32, 42, and 40% starting from easily available ursolic acid ( 4 ), oleanolic acid ( 5 ), and betulin ( 6 ), respectively. Remarkably, these three natural pentacyclic triterpenes exhibited potential inhibitory activity against human oxidosqualene cyclase.